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朱清

作者:金飞     日期:2021-10-26   点击数:53  

师资介绍



朱清,男,汉,1978.08,副教授,博士,天然药物系副主任


研究方向

神经药理学与药物代谢


基金项目

  1. 国家自然科学基金面上项目,82071238,基于疼痛抑制行为探讨去甲青藤碱靶向α2-GABAA受体的镇痛效应,2021/01-2024/1255万,在研,主持(PI

  2. 江苏省自然科学基金面上项目,BK20181459,基于疼痛抑制行为的去甲青藤碱镇痛效应及与GABAA受体相关机制研究,2018/07-2021/0610万,在研,PI

  3. 江苏省自然科学青年基金项目,BK20181459,益母草碱抗心肌缺血作用及药效物质基础的代谢组学研究,2013/07-2016/0620万,结题,PI

  4. 国家自然科学基金面上项目,81971243TAAR1-CaMKII-CREB信号通路调节尼古丁成瘾,2020/01-2023/1255万,在研,Co-PI协助主持

  5. 国家自然科学基金面上项目,81373390,选择性咪唑啉I2受体配体的镇痛效应及滥用潜力研究,2014/01-2017/1265万元,结题,Co-PI


科研成果

  1. 朱清, 李俊旭, 苏漫, 李洁佳, 欧云淘,一种镇痛药物组合物,2021/03/19

中国,ZL201710671939.4 (授权专利)   

  1. 朱清,卫蒨蒨,唐文婷,李俊旭,潘菲,邱男青,周致用,李洁佳, 氧化前胡素的新用途,2020/05/08,中国 ZL201810813028.5(授权专利)  

  2. 朱清,李俊旭,卫蒨蒨,潘菲,邱男青,李洁佳,氧化前胡素在制备治疗术后疼痛药物中的应用,2020/04/28,中国 ZL201810751676.2 (授权专利)  

  3. 朱清,李俊旭,孙越华,青藤碱在制备治疗慢性疼痛伴抑郁行为药物中的应用,2017/01/04中国,ZL201410456667.2(授权专利)  

  4. 李俊旭,朱清,欧云淘,苏漫,赵颖,去甲青藤碱在制备镇痛药物中的应用,2019/12/20 中国,ZL201610331233.9(授权专利)  

  5. 李俊旭,朱清,毛丽娜,刘成鹏,孙越华,牡荆素在制备治疗术后疼痛中的应用,2017.11.07,中国,ZL201510642790.8(授权专利)  


代表性论文

  1. Zhiyong Zhou, Nanqing Qiu, Yuntao Ou, QianqianWei, WentingTang,MingcongZheng, Yaluan Xing, Jie Jia Li, Yong Ling, Junxu Li* & Qing Zhu*. Demethylsinomenine, an active metabolite of sinomenine, attenuates chronic neuropathic and infammatory pain in mice. Scientifc Reports, 2021, 11:9300.  (Corresponding author)

  2. Yuntao Ou, Man Su, Yong Ling, Qianqian Wei, Fei Pan, Jiejia Li, Jun-Xu Li*, Qing Zhu*. Anti-allodynic effects of N-demethylsinomenine, an active metabolite of sinomenine, in a mouse model of postoperative pain. Eur. J. Pharmacol. 2018, 823:105–109. DOI: 10.1016/j.ejphar.2018.01.044. (Corresponding author)

  3. Yong Ling, Jing Guo, Qiuxing Yang, Peng Zhu, Jiefei Miao, Weijie Gao, Yanfu Peng, Jiaying Yang, Kun Xu, Biao Xiong, Gongqing Liu, Jinhua Tao, Lin Luo, Qing Zhu*, Yanan Zhang*. Development of novel β-carboline-based hydroxamate derivatives as HDAC inhibitors with antiproliferative and antimetastatic activities in human cancer cells. Eur J Med Chem. 2018, 144:398-409.  (Corresponding author)

  4. Qing Zhu, Yuehua Sun, Lina Mao, Chengpeng Liu, Bo Jiang, Wei Zhang & Jun-Xu Li. Antinociceptive effects of sinomenine in a rat model of postoperative painBritish Journal of Pharmacology, 2016, 173:1693-1702.

  5. Qing Zhu, Li-Na Mao, Cheng-Peng Liu, Yue-Hua Sun, Bo Jiang, Wei Zhang & Jun-Xu Li. Antinociceptive effects of vitexin in a mouse model of postoperative pain. Scientific Reports, 2016, 6:19266.

  6. Qing Zhu, Yuehua Sun, Jie Zhu, Tian Fang, Wei Zhang & Jun-Xu Li. Antinociceptive effects of sinomenine in a rat model of neuropathic pain. Scientific Reports, 2014, 4: 7270.

  7. Qing Zhu, Yuehua Sun, Xiaodi Yun, Yuntao Ou, Wei Zhang & Jun-Xu Li. Antinociceptive effects of curcumin in a rat model of postoperative pain, Scientific Reports, 2014, 4:4932.

  8. Qing Zhu, Jinlian Zhang, Ping Yang, Bo Tan, Xinhua Liu, Yuanting Zheng, Weimin Cai & Yizhun Zhu. Characterization of Metabolites of Leonurine (SCM-198) in Rats after Oral Administration by Liquid Chromatography/Tandem Mass Spectrometry and NMR Spectrometry, The Scientific World Journal, 2014, 2014:947946.

  9. Qing Zhu, Weimin Cai, Xianyi Sha, Guo Ma, Yuanting Zheng, Xueru Shi & Yizhun Zhu. Quantification of leonurine, a novel potential cardiovascular agent, in rat plasma by liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic study in rats, Biomedical Chromatography, 2012, 26(4): 518-523.

  10. Jie-Jia Li#, Qing Zhu# (Co-First Author), Ya-Peng Lu, Peng Zhao, Zhan-Bo Feng, Zhong-Ming Qian & Li Zhu. Ligustilide prevents cognitive impairment and attenuates neurotoxicity in D-galactose induced aging mice brain, Brain Research, 2015,1595:19-28.

  11. Donggeng Wang#, Qing Zhu # (Co-First Author), Baohua Liu, Guangtong Chen & Yong Ling. Identification of gut microbial metabolites of a synthetic nitric oxide-releasing farnesylthiosalicylic acid derivative, an antitumor agent, Analytical Letters, 2014, 47(2):191-201.

  12. Qing Zhu, Jinhua Gu, Hongyan Zhu & Jiliang Xu. Identification of differentially expressed genes in dorsal root ganglion in early diabetic rats, Neuroscience Bulletin, 2008, 24(4):219-24.