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许伯慧

作者:金飞     日期:2021-10-26   点击数:32  

师资介绍


姓名:许伯慧

性别:女

民族:汉

出生年月:1982.09

职称:副教授

学历:博士研究生


研究方向:

药剂学,生物大分子药物递送系统


基金项目:

  1. 国家自然科学基金委员会,青年科学基金项目,81803454,利用肿瘤微环境逐级响应型siRNA层释系统双重阻断基于CXCR4/CXCL12信号轴的肿瘤转移,2019-012021-1221万,在研,主持;

  2. 南通市科技局,南通市市级科技课题,JC2021116,双生异靶型siRNA递送系统用于全面阻断基于趋化因子信号轴的肝细胞癌的发展及转移,2021-072023-063万元,在研,主持;

  3. 南通市科技局,南通市市级科技课题,MS12015064,以视黄醇-蛋白结合物为导向的脂质蛋白复合纳米基因递送载体的构建及抗肝纤维化的研究,2015-102018-093万元,已结题,主持;

  4. 江苏省教育厅,江苏省高校自然科学研究面上项目,15KJD350002,蛋白冠状物导向的肝星状细胞靶向递药系统的研究,2015-072017-061.5万元,已结题,主持。


科研成果

1. 代表性论文

(1) Yang, Han; Liu, Tingting; Xu, Yan; Su, Gaoxing; Liu, Tianqing; Yu, Yanyan*; Xu Bohui*; Protein corona precoating on redox-responsive chitosan-based nano-carriers for improving the therapeutic effect of nucleic acid drugs, Carbohydrate Polymers, 2021,256:118071.

(2) Xu, Bohui#; Zhang, Yan; Yang, Han; Liu, Tingting; Lu, Youjia; Xu, Yan; Zhang, Qifeng; Li, Xingyu; Huang, Zhiqi; Zhang, Yuanyuan*; Webster Tomas*; siVEGF-loaded nanoparticle uptake by tumor-associated vascular endothelial cells for hepatocellular carcinoma, Nanomedicine(Lond.), 2020,15(13):1297-1314.

(3) Xu, Bohui; Xu, Yan; Su, Gaoxing; Zhu, Hongyan; Zong, Li*; A multifunctional nanoparticle constructed with a detachable albumin outer shell and a redox-sensitive inner core for efficient siRNA delivery to hepatocellular carcinoma cells, Journal of Drug Targeting,2018,26(10): 941-954.

(4) Xu, Bohui; Zhang, Wenjing; Chen, Yulin; Xu, Yan; Wang, Bo; Zong, Li*Eudragit (R) L100-coated mannosylated chitosan nanoparticles for oral protein vaccine delivery, International Journal of Biological Macromolecules,2018,113:534-542.

(5) Liu, Yali; Li, Peng; Qian, Rong; Sun, Tianyu; Fang, Fangzhi; Wang, Zonghua; Ke, Xue; Xu, Bohui*; A novel and discriminative method of in vitro disintegration time for preparation and optimization of taste-masked orally disintegrating tablets of carbinoxamine maleate, Drug Development and Industrial Pharmacy,2018,44(8):1317-1327.

(6) Xu, Bohui; Wang, Yubin; Zhu, Hongyan*; Mini-tablet combination for sustained release of clonidine hydrochloride and hydrochlorothiazide: Preparation and pharmacokinetics in beagle dogs, Pharmazie,2016,71(2): 76-83.


2. 专利

许伯慧;许燕;朱红艳;苏高星;一种壳-核结构的siRNA仿病毒递送系统及应用,2020-10-30,中国,ZL201711155278.6